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Feeling of your concept of bronchopulmonary dysplasia for the neurodevelopmental outcomes

Feeling of your concept of bronchopulmonary dysplasia for the neurodevelopmental outcomes

Understanding the short and long-term pulmonary and neurologic outcomes of neonates with bronchopulmonary dysplasia (BPD) is important in neonatal care for low-birth-weight infants. Different criteria for BPD may have different associations with long-term outcomes. Currently, two criteria for diagnosing BPD have been proposed by the NIH (2001) and NRN (2019) for preterm infants at a postmenstrual age (PMA) of 36 weeks. We investigated which BPD definition best predicts long-term outcomes. Korean nationwide data for preterm infants born between 24 +0 and < 32 +0 weeks gestation from were collected. For long-term outcomes, severity based on the NRN criteria was significantly related to neurodevelopmental impairment (NDI) in a univariate analysis after other risk factors were controlled. For the admission rate for respiratory disorder, grade 3 BPD of the NRN criteria had the highest specificity (96%), negative predictive value (86%), and accuracy (83%). For predicting NDI at the 18–24 month follow-up, grade 3 BPD of the NRN criteria had the best specificity (98%), positive (64%) and negative (79%) predictive values, and accuracy (78%) while NIH severe BPD had the highest sensitivity (60%). The NRN definition was more strongly associated with poor 2-year developmental outcomes. BPD diagnosed by NRN definitions might better identify infants at high risk for NDI.


Bronchopulmonary dysplasia (BPD) is a major side effect from inside the very low birth lbs babies (VLBWIs). More serious BPD try of an increased probability of developmental handicap and shorter pulmonary form 1,2,3 . The medical span of the disease, such as the dependence on rehospitalization and you may neurodevelopmental impairment, are a reported question certainly mothers and you may medical care organization 4 . Understanding how state seriousness try from the developmental reduce and readmissions will help publication upcoming search and you will quality upgrade initiatives to attenuate the duty associated with the infection Video dating site.

BPD was discussed of the Northway et al. 5 more than half a century before; yet not, into the 2001, the fresh new National Institute of Child Wellness (NIH) revised brand new categorical significance off BPD. More recently, inter-heart variability inside fresh air government and you may nasal cannula move, and the entry to noninvasive venting, is also prejudice the brand new NIH class off BPD presence and you can seriousness. In other words, these types of widely used conditions may not be acceptable for the current logical disease or even the forecast out of enough time-title results of modern-day VLBWIs 6,eight . According to so it discrepancy, Jensen et al. 8 suggested an alternative definition of BPD you to definitely top predict very early youth morbidity and you can categorized condition severity with regards to the means from respiratory support, whatever the access to extra outdoors. That it meaning try changed so you can significantly more precisely anticipate breathing readmission and developmental delays from inside the a beneficial U.S.-created people.

And therefore, i aimed to decide and therefore definition of BPD in the a beneficial PMA away from thirty-six weeks try most appropriate to own anticipating enough time-term neonatal outcomes, for example pulmonary and you can neurologic effects, measured during the 18–two years fixed decades (CA), when you look at the a multicenter cohort examination of VLBWIs in line with the across the country Korean Neonatal Community (KNN) registry.


A maximum of 8294 children produced between 24 +0 days and you can 29 +six days GA have been entered to the KNN, Immediately after excluding babies, 2889 VLBWIs remained; among them, 1849 (64.0%) had complete follow-upwards pointers offered by California 18–24 months, plus respiratory readmission and you will developmental effects (Fig. 1). Of those 1849 VLBWIs, 1221 (66.0%) got BPD according to NIH meaning, and 665 babies (36%) with lightweight BPD, 184 babies (10%) that have moderate BPD, and you will 372 kids (19%) having big BPD. On the other hand 555 kids (30%) had BPD according to the NRN meaning, together with 186 infants (10%) which have degrees step one BPD, 303 babies (16%) with level dos BPD, and 66 infants (4%) having degrees step 3 BPD (Dining table 1).

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